This message usually appears because the file has been moved to another location via Windows® Explorer. To open the file with ScanSnap Home, return the moved file to the original place.
Example
To solve the error message below, move or copy ScanSnap.pdf to the following place:
C:\Users\ScanSnap\Appdata\Roaming\PFU\ScanSnap Home
If the file to return is gone, delete the remaining content data on ScanSnap Home and scan the image again.